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Hi Physician Ben, I have a heterozygous mutation to the C677t and A1298, I started out on 200mcg of 5mthf, then after a week moved as much as 400 mcg and stayed on that for weekly or so. I then extra 1 mg of methylb12 and had some adverse reactions. I had intense chest agony all-around my coronary heart and also in the center of my upper body. Grea